Study of Release Kinetics and Statistical Optimization of Slow Release Effervescent Tablet Containing Ibuprofen
نویسندگان
چکیده
2 The work investigates the formulation development, evaluation and optimization of ibuprofen effervescent tablet using 3 factorial designs. The effect of variables viz. xanthan gum and sodium bicarbonate on drug release and hardness of ibuprofen effervescent tablets were analyzed and optimized. The optimized formulation showed the ibuprofen release in sustained manner over a period of 6h. The percentage drug release at 6h 2 and hardness for optimized formulation was found to be 72.25±1.85 and 4.50±0.05 kg/cm . Ibuprofen effervescent tablets followed KorsmeyerPepas model with anomalous (non-Fickian) diffusion mechanism.
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